Michael E Berens Selected Research

Therapeutics

2/2024	Novel Brain-Penetrant, Small-Molecule Tubulin Destabilizers for the Treatment of Glioblastoma.
12/2020	Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma.
1/2020	Temporospatial genomic profiling in glioblastoma identifies commonly altered core pathways underlying tumor progression.
10/2019	A pilot precision medicine trial for children with diffuse intrinsic pontine glioma-PNOC003: A report from the Pacific Pediatric Neuro-Oncology Consortium.
1/2019	PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
10/2018	When the Ends Are Really the Beginnings: Targeting Telomerase for Treatment of GBM.
1/2018	Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma.
1/2018	Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation.
11/2017	Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.
10/2017	Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.

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Michael E Berens Research Topics

Disease

55	Neoplasms (Cancer) 02/2024 - 04/2003
44	Glioma (Gliomas) 01/2023 - 02/2002
29	Glioblastoma (Glioblastoma Multiforme) 02/2024 - 02/2002
7	Brain Neoplasms (Brain Tumor) 01/2020 - 04/2007
3	Diffuse Intrinsic Pontine Glioma 01/2023 - 10/2019
3	Carcinogenesis 09/2017 - 04/2006
3	Disease Progression 05/2015 - 11/2007
2	Medulloblastoma 12/2020 - 01/2016
2	Sarcoma (Soft Tissue Sarcoma) 12/2020 - 01/2017
2	Astrocytoma (Pilocytic Astrocytoma) 09/2012 - 03/2010
1	Central Nervous System Neoplasms 01/2023
1	Brain Stem Neoplasms (Brain Stem Tumor) 01/2023
1	Thyroid Neoplasms (Thyroid Cancer) 01/2020
1	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 01/2020
1	Kaposi Sarcoma (Kaposi's Sarcoma) 01/2020
1	Laryngeal Neoplasms (Laryngeal Cancer) 01/2020
1	Edema (Dropsy) 01/2019
1	Retinoblastoma (Glioblastoma, Retinal) 09/2017
1	Melanoma (Melanoma, Malignant) 01/2017
1	Carcinoma (Carcinomatosis) 01/2017
1	Genomic Instability 01/2017
1	Prostatic Neoplasms (Prostate Cancer) 01/2017
1	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 02/2016
1	Alzheimer Disease (Alzheimer's Disease) 02/2016
1	Seizures (Absence Seizure) 05/2015
1	Typical Teratoid Rhabdoid Tumor 09/2014

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 11/2022 - 04/2003
9	Small Interfering RNA (siRNA)IBA 03/2016 - 11/2004
6	Temozolomide (Temodar)FDA LinkGeneric 02/2024 - 04/2007
6	RNA (Ribonucleic Acid)IBA 01/2020 - 01/2018
6	Messenger RNA (mRNA)IBA 01/2020 - 04/2003
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2017 - 02/2005
5	DNA (Deoxyribonucleic Acid)IBA 11/2023 - 09/2014
5	Biomarkers (Surrogate Marker)IBA 11/2022 - 04/2007
5	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 02/2017 - 02/2005
5	Phosphotransferases (Kinase)IBA 08/2014 - 03/2003
5	LigandsIBA 12/2013 - 09/2006
4	dipinacoline glutamateIBA 01/2023 - 01/2019
4	Transcription Factors (Transcription Factor)IBA 02/2017 - 01/2013
3	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 03/2016 - 12/2008
3	IntegrinsIBA 06/2009 - 03/2003
3	TWEAK ReceptorIBA 11/2007 - 04/2003
2	LipidsIBA 11/2017 - 01/2017
2	Mitogen-Activated Protein KinasesIBA 09/2017 - 04/2007
2	CamptothecinIBA 02/2015 - 11/2003
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 08/2014 - 01/2012
2	Tyrosine (L-Tyrosine)FDA Link 12/2013 - 03/2003
2	EphrinsIBA 12/2013 - 09/2006
2	GTP Phosphohydrolases (GTPases)IBA 10/2013 - 09/2012
2	Monomeric GTP-Binding ProteinsIBA 09/2012 - 12/2008
2	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2012 - 03/2003
2	Peptides (Polypeptides)IBA 06/2009 - 09/2005
2	OligonucleotidesIBA 12/2008 - 03/2005
2	Glycogen Synthase (Synthase I)IBA 10/2008 - 11/2003
2	NF-kappa B (NF-kB)IBA 10/2006 - 04/2006
2	Ephrin-B3 (Ephrin B3)IBA 09/2006 - 01/2005
2	matrigelIBA 10/2005 - 11/2004
2	Focal Adhesion Kinase 2IBA 05/2005 - 03/2003
1	TubulinIBA 02/2024
1	NucleotidesIBA 11/2023
1	Cell-Free Nucleic AcidsIBA 11/2023
1	Immune Checkpoint InhibitorsIBA 01/2023
1	Chimeric Antigen ReceptorsIBA 01/2023
1	quisinostatIBA 01/2023
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2023
1	Histones (Histone)IBA 01/2023
1	Histone Deacetylase InhibitorsIBA 01/2023
1	pevonedistatIBA 11/2022
1	Dactinomycin (Actinomycin)FDA LinkGeneric 12/2020
1	insulin receptor-related receptor (IRR)IBA 01/2020
1	IronIBA 01/2020
1	Unithiol (DMPS)IBA 01/2020
1	Nicotinamide PhosphoribosyltransferaseIBA 01/2019
1	NAD (NADH)IBA 01/2019
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2019
1	Telomerase (Telomerase Reverse Transcriptase)IBA 10/2018
1	Eukaryotic Initiation Factor-4EIBA 01/2018
1	Arsenic Trioxide (Trisenox)FDA Link 01/2018
1	adavosertibIBA 01/2018
1	Gonadal Steroid Hormones (Sex Hormones)IBA 01/2018
1	Aurintricarboxylic AcidIBA 02/2017
1	Aquaporins (Water Channels)IBA 01/2017
1	Peroxidase (Myeloperoxidase)IBA 01/2017
1	Lipid PeroxidesIBA 01/2017
1	Alkylating AgentsIBA 03/2016
1	propentofyllineIBA 02/2016
1	methylxanthineIBA 02/2016
1	Protein Kinases (Protein Kinase)IBA 01/2016
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 09/2015
1	Adenosine Monophosphate (AMP)IBA 09/2015
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 09/2015
1	Glutamic Acid (Glutamate)FDA Link 05/2015
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 02/2015
1	Polylactic Acid-Polyglycolic Acid CopolymerIBA 02/2015

Therapy/Procedure

29	Therapeutics 02/2024 - 11/2003
7	Drug Therapy (Chemotherapy) 12/2020 - 03/2005
7	Lasers (Laser) 03/2010 - 05/2004
6	Radiotherapy 12/2018 - 10/2006
4	Precision Medicine 12/2020 - 08/2015
1	Investigational Therapies (Experimental Therapy) 01/2023